Fetal spleen stroma drives macrophage commitment

Fetal spleen stroma drives macrophage commitment.

The role of the fetal spleen in hematopoeisis remains largely unknown. In this particular environment, we show that hematopoietic stem cells do not proliferate, but that they lose multipotency and differentiate exclusively into mature macrophages. B lymphocytes in the spleen derive from committed B cell precursors that are likely to have immigrated from the fetal liver. We developed fetal splee...

IκB kinase activity drives fetal lung macrophage maturation along a non-M1/M2 paradigm.

In preterm infants, exposure to inflammation increases the risk of bronchopulmonary dysplasia, a chronic, developmental lung disease. Although macrophages are the key cells that initiate lung inflammation, less is known about lung macrophage phenotype and maturation. We hypothesized that fetal lung macrophages mature into distinct subpopulations during mouse development, and that activation cou...

IkB Kinase Activity Drives Fetal Lung Macrophage Maturation along a Non-M1/M2 Paradigm

Dynamic stroma reorganization drives blood vessel dysmorphia during glioma growth

Glioma growth and progression are characterized by abundant development of blood vessels that are highly aberrant and poorly functional, with detrimental consequences for drug delivery efficacy. The mechanisms driving this vessel dysmorphia during tumor progression are poorly understood. Using longitudinal intravital imaging in a mouse glioma model, we identify that dynamic sprouting and functi...

Innate immune functions of macrophage subpopulations in the spleen.

In the different compartments of the spleen, macrophage populations can be found that have different functions depending on their localization. In the lymphoid compartment of the spleen, the white pulp, macrophages are in essence similar to populations found in lymph nodes and other organized secondary lymphoid organs. In the red pulp, large populations of classical scavenger macrophages are fo...